vitamins c, e and lipid peroxidation levels in sperm and seminal plasma of asthenoteratozoospermic and normozoospermic men

نویسندگان

mohammad nouri

aliyeh ghasemzadeh

laya farzadi

vahideh shahnazi

چکیده

background: it has been shown that reactive oxygen species (ros) can lead to deleterious effects on a range of sperm parameters. vitamins e and c are capable of reducing ros levels and lipid peroxidation. objective: the aim of study was to determine the level of lipid peroxidation as indicated by malondialdehyde (mda) and vitamins e and c in sperm and seminal plasma of asthenoteratozoospermic and normozoospermic men and their relationships with semen parameters. materials and methods: forty men with normozoospermic and 60 infertile men with asthenoteratozoospermic semen profiles were randomly selected. semen analysis was done according to the who standard. sex hormonal profiles were measured by elisa methods. the level of vitamins (c and e) and mda were measured by hplc and tiobarbiotic acid, respectively. results: mda concentration in the spermatozoa (0.10.06 nmol/ml) and seminal plasma (1.90.35 nmol/ml) of asthenoteratozoospermic were significantly higher than in normozoospermic males (p<0.001).the level of vitamins e and c in seminal plasma of normozoospermic were significantly higher than in asthenoteratozoospermic males (p<0.01). however, the amount of vitamin c in the spermatozoa of normozoospermic was significantly less than in asthenoteratozoospermic males (p<0.01). sensitivity, specificity, positive and negative prognostic value of mda of seminal plasma and spermatozoa were more than vitamins c and e. the level of vitamin c of spermatozoa had more diagnostic value when compare to vitamins c and e in seminal plasma. conclusion: the level of mda in seminal plasma and spermatozoa and vitamin c in spermatozoa may be a diagnostic tool for etiology of infertility in the asthenoteratozoospermic patients.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Vitamins C, E and lipid peroxidation levels in sperm and seminal plasma of asthenoteratozoospermic and normozoospermic men

Background: It has been shown that reactive oxygen species (ROS) can lead to deleterious effects on a range of sperm parameters. Vitamins E and C are capable of reducing ROS levels and lipid peroxidation. Objective: The aim of study was to determine the level of lipid peroxidation as indicated by Malondialdehyde (MDA) and vitamins E and C in sperm and seminal plasma of asthenoteratozoospermic a...

متن کامل

Correlation between Seminal Fluid Analysis and Levels of Gonadotropins in Serum and Seminal Plasma of Normozoospermic Men and Infertile Patients

Background Levels of serum gonadotropins have direct effects on testicular functions and spermatogenesis. Assessment of levels of serum gonadotropins from fathered subjects and infertile patients indicates wide range diversity. In this study, we tried to find out whether the levels of seminal FSH and LH affect the parameters of seminal fluid analysis (SFA) and if there is any correlation betwee...

متن کامل

RELATIONSHIP OF SPERM PARAMETERS WITH LIPID PEROXIDATION IN ASTHENOZOOSPERMIC AND NORMOZOOSPERMIC MALES

Background: The lipid peroxides and their degradation products are highly toxic to spermatozoa and may play a major role in sperm dysfunction. The purpose of this study was to determine the level of lipid peroxidation as indicated by malondialdehyde (MDA) in the spermatozoa and seminal plasma of asthenozoospermic and normozoospermic males. In addition, correlation of lipid peroxidation with mot...

متن کامل

Correlation between Seminal Fluid Analysis and Levels of Gonadotropins in Serum and Seminal Plasma of Normozoospermic Men and Infertile Patients

Background: Levels of serum gonadotropins have direct effects on testicular functions and spermatogenesis. Assessment of levels of serum gonadotropins from fathered subjects and infertile patients indicates wide range diversity. In this study, we tried to find out whether the levels of seminal FSH and LH affect the parameters of seminal fluid analysis (SFA) and if there is any correlation betwe...

متن کامل

plasma antioxidant vitamins levels and lipid peroxidation in breast cancer patients

oxidative stress arises when there is an imbalance between reactive oxygen species (ross) and scavenging capacity of antioxidants, and it can induce and progress many diseases such as breast cancer. the present study was conducted to investigate the status of plasma antioxidative vitamins (e and c) and lipid peroxidation on 50 untreated breast cancer patients and 50 healthy age-matched women. t...

متن کامل

Research Paper: Correlation Between Serum and Seminal Leptin and Nitric Oxide (Nitrite) in Asthenote-ratozoospermic Males

Introduction: Leptin is a critical metabolic signal linking nutrition and reproductive functions. Leptin receptors are expressed in germ cells, Sertoli and Leydig cells. Oxidative stress increases sperm DNA damages. Nitric oxide is a free radical, produced by most cells via Nitric Oxide (NO) synthase and plays stimulatory and inhibitory roles on cells. Physiological concentrations of NO are ess...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
international journal of reproductive biomedicine

جلد ۶، شماره ۱، صفحات ۱-۰

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023